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KMID : 1145520200060010020
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Journal of Radiopharmaceuticals and Molecular Probes
2020 Volume.6 No. 1 p.20 ~ p.26
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Study on production process of graphite for biological applications of 14C-accelerator mass spectrometry
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Ha Yeong-Su
Kim Kye-Ryung
Cho Yong-Sub
Choe Kyun-Min
Kang Chae-Won
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Abstract
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Accelerator mass spectrometry (AMS) is a powerful detection technique with the exquisite sensitivity and high precision compared with other traditional analytical techniques. Accelerator mass spectrometry can be widely applied in the technique of radiocarbon dating in the fields of archeology, geology and oceanography.
The ability of accelerator mass spectrometry to measure rare 14C concentrations in microgram and even sub-microgram amounts suggests that extension of 14C-accelerator mass spectrometry to biomedical field is a natural and attractive application of the technology. Drug development processes are costly, risky, and time consuming. However, the use of 14C-accelerator mass spectrometry allows absorption, distribution, metabolism and excretion (ADME) studies easier to understand pharmacokinetics of drug candidates. Over the last few decades, accelerator mass spectrometry and its applications to preclinical/clinical trials have significantly increased. For accelerator mass spectrometry analysis of biological samples, graphitization processes of samples are important. In this paper, we present a detailed sample preparation procedure to apply to graphitization of biological samples for accelerator mass spectrometry.
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KEYWORD
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Accelerator mass spectrometry, Radiocarbon, Graphitization, Multidisciplinary research, Biological applications
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